Historically, pathology services associated with transperineal Prostate Saturation Biopsy (PSB) have been reported with CPT code 88305. CMS determined that separate billing for transperineal PSB samples resulted in significant overpayments for the amount of work involved in performing these services. Effective for dates of service on or after 1/1/2009, CMS implemented four new HCPCS codes to more accurately represent the pathologic evaluation, interpretation, and report for these services.