This article is intended to provide additional guidance to the laboratory community in meeting the new requirements under Section 1834A of the Social Security Act (the Act) for the Medicare Part B Clinical Laboratory Fee Schedule (CLFS). The data reporting period for the CLFS opened on January 1, 2017. CMS has developed an online data collection system to assist laboratories in submitting data to CMS, which are due by March 31, 2017. A detailed user guide on how to access and use this system is available at https://www.cms.gov/Medicare/Medicare-Fee-for-Service-Payment/ClinicalLabFeeSched/PAMA-Regulations.html. Laboratories must designate both a CLFS submitter and CLFS certifier in the data collection system. These must be two different individuals. The CLFS submitter must be registered in Medicare's Provider Enrollment, Chain and Ownership System (PECOS) as a User or Authorized User on the PECOS Medicare Enrollment forms (in other words CLFS submitters must have their name appear within one of the following 855 application forms: A,B,C,I,R). The CLFS certifier does not need to be registered in PECOS. A data reporting template is available at https://www.cms.gov/Medicare/Medicare-Fee-for-Service-Payment/ClinicalLabFeeSched/PAMA-Regulations.html. Laboratories seeking to upload their data to the CLFS data collection system should use this template.