Laboratory Information System

XIFIN LIS 5 is the only SaaS-based LIS platform that offers multi-specialty workflows and collaboration tools necessary to support precision medicine programs.


Increases laboratory testing capacity, shortens turnaround time, creates new revenue stream opportunities and makes it easier to connect to other healthcare partners. XIFIN LIS improves operational efficiencies and delivers flexibility necessary for today’s laboratories to thrive.

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Extending the Laboratory’s Role in the Healthcare Ecosystem

In response to value-based and patient-centered coordinated care models, the healthcare industry is shifting. Accelerating the shift is the exponential growth in personalized medicine and new interoperability and reporting requirements.  Since diagnostic insights have the potential to reduce overall healthcare costs and improve patient care – it is crucial that laboratories better integrate with the healthcare ecosystem. These demands are driving the need for more interaction and greater communication across all healthcare and diagnostic providers. 

In this environment, an integrated LIS is a critical and central component in an efficient laboratory operations strategy. Laboratories need their technology infrastructure to support new initiatives, drive out inefficiencies, optimize their operations, and enable them to easily respond to business demands. There is no doubt that a laboratory’s LIS is the day-to-day workhorse and therefore it must be architected to meet these new demands. Those that are proactively addressing challenges and opportunities in the healthcare industry see their LIS as a critical success factor and an investment.


XIFIN LIS is the most advanced laboratory information system available today. With the XIFIN technology platform as its foundation, XIFIN LIS facilitates the open but secure exchange of diagnostic, financial, and clinical information. It is a SaaS-based diagnostic solution that connects all laboratory operational components, including test ordering, lab workflow management, transcription, reporting, billing, and financial management within a single, easy-to-use, platform. It can be used as a stand-alone LIS that manages multiple test specialties, or it can be utilized to supplement the capabilities of an existing LIS that may not support a specific type of test.

Whether your facility is an early-stage molecular or genomics laboratory, an established pathology practice experiencing growth, or a mature clinical lab looking to gain efficiencies and create new revenue streams, XIFIN LIS is specifically designed to meet the varied operational needs and regulatory requirements for every kind of diagnostic laboratory.

William Blair Report: Next-Generation-Sequencing Trends in the Clinical Lab Space

William Blair conducted a survey in collaboration with The Dark Report and XIFIN to better understand next-generation sequencing trends in the clinical lab space.


XIFIN LIS increases laboratory testing capacity, shortens turn around time, enables the creation of new revenue models, improves operational efficiencies and makes it easier to connect to other healthcare partners. XIFIN’s modular approach provides laboratories the flexibility to choose only those workflows they require to meet their immediate needs and to readily add more when required to scale.

New Revenue Models

Esoteric Testing Modules

Expand services with flexible workflow and reporting programs for FISH, Flow, IHC, Cytogenetics, Molecular testing.

TC/PC Splits

Use multi-entity architecture and dynamic workflow design to easily separate technical and professional components of diagnostic tests for revenue sharing programs.

Secondary Consultation Opportunities

Offset reduced reimbursement with new secondary consultation revenue through secure, cost-effective digital pathology collaboration.

Improve Operational Efficiency

Ultimate Workflow Visibility

See what tests are being run, where they are in the process, and what steps are next. XIFIN LIS maintains a full audit trail that document who did what and when and what changes were made to the sample.

Highly Configurable Solution Delivers the Flexibility You Need

Leverage end-user configuration toolsets to manage workflow updates, user privileges and dynamic elements such as reference ranges and reagent information. Input screens can be tailored to capture unique data elements for case-specific reporting requirements.

Access from Anywhere and Always Up to Date

XIFIN LIS is hosted at the premier Tier 5 co-location facility, built on high availability architectures and is accessible from anywhere with an internet connection. Plus, SaaS delivery ensures you will always be using the latest version, without ever having to deal with maintenance or costly, time-consuming software updates.

Advanced Capabilities Extend the LIS Beyond the Laboratory

Multidisciplinary Care Team Collaboration

To support collaboration and consultation, pathologists, radiologists, and oncologists can securely upload as well as synchronously and asynchronously view and annotate whole slide digital images, DICOM, and other medical images associated with a particular case. In addition to improving patient outcomes, these capabilities also open up new revenue opportunities for labs that help offset diminishing reimbursements.

Universal Image Management

Real-time and secure exchange of medical images eliminates the need to ship patient images to other locations, drastically reducing the risk of loss or unauthorized access to patient data. Secure electronic access to medical images in conjunction with automated workflows also eliminates delays and reduces cost.

Digital Pathology Consultations

Pathologists can extend their digital pathology consultation capabilities outside their practice or hospital system to easily offer or solicit secondary consults in a sub-specialty.  Pathologists can collaborate and consult with colleagues over a secure network, which increases opportunities to work together on complex cases and improve patient outcomes.

The First Laboratory Information System with
Integrated Prior Authorization Capabilities

The First Laboratory Information System with Integrated Prior Authorization Capabilities

Each year, $31 billion is spent on prior authorizations, and 40% of prior authorizations are abandoned due to complex approval policies. As increasingly complicated tests enter the market, labs need more efficient ways to secure prior authorizations to efficiently give patients the diagnostic information they need, while also getting reimbursed without delay. In partnership with Glidian, XIFIN LIS is the first laboratory information system to have integrated, automated prior authorization capabilities to overcome this issue. When using Glidian and XIFIN LIS together, customers experience a simplified prior authorization process and increased revenue.

Unified Dashboard

Submit and track all your authorizations through a single dashboard and receive real-time notifications when the status of a case changes. Approved cases will include dates of approval, approved codes, and authorization numbers - all without the need to fax or call health plans.

Prevent Denials

Our system incorporates insurance-specific requirements from medical policies and automatically updates as policies change. Our machine learning algorithm learns from previous submissions to prevent denials.

Analytics & Reports

Receive reports for your internal metrics to measure the success of your prior authorizations and gain insight into reasons for denial. You can sort by insurance company, procedure, and submitter to improve your internal process.

Test-Specific Automation Gets You Started Quickly

XIFIN LIS automates and manages your diagnostic workflows—regardless of complexity or volume.  With configuration driven automated workflow modules supporting 17 different testing specialties, it is easy to get started.

Anatomic Pathology

Amid changing healthcare models, pathologists are seeing increasing demand for comprehensive reporting, collaboration, and data sharing to support multidisciplinary teams.

Workflows include:​


Immunohistochemistry (IHC)/Special Stains

Gynecological Cytology

Non-Gynecological Cytology



Bone Marrow Morphology

Flow Cytometry


Clinical Pathology

Clinical and toxicology laboratories are under pressure to optimize operational efficiencies in an increasingly challenging reimbursement environment. Higher throughput without compromising quality requires a flexible laboratory information system that can manage significant workflow variety, actively manage worklists and sample progress and take advantage of electronic connectivity from the EMR through the billing process.​

Workflows include:​





Molecular Diagnostics

The advance in human genotyping and a transition to a value-based model is driving growth in molecular diagnostic (MDx) testing and complementary services. This expansion is creating data and workflow management, reporting, compliance, and specialty testing reimbursement policy issues that must be solved for today’s MDx labs to thrive.

Workflows include:​


Chromosomal Micro-Array



The frequency and cost of adverse drug events (ADEs), coupled with a shift towards a value-based healthcare model is forcing a rapid change in the healthcare landscape. As a result, the utility and application in the clinical environment  of pharmacogenomics (PGx) and next-generation sequencing (NGS) test is increasing 

To be successful, PGx and NGS focused laboratories must be equipped to solve the data and workflow management, reporting, compliance, and challenging reimbursement policies that are being created.

Workflows include:​


Sanger Sequencing


Data & Workflow Management

Combining processing efficiency, workflow optimization, quality assurance, and data validation, XIFIN LIS enables laboratories to stay competitive in an increasingly complex environment. Additionally, the cloud-based SaaS architecture removes costly IT requirements, easily scales to meet the needs of laboratories of any size, and facilitates collaboration and information sharing across systems in a two-way "digital conversation."

In as little as 45 days, XIFIN LIS can be integrated and configured to connect all laboratory operational components allowing for a global, real-time view of lab activities and the automation of critical workflow steps.

This connectivity allows for a single point of entry for all laboratory processes via an intuitive, laboratory-friendly solution. Streamlining these procedures and increasing efficiencies allows laboratory staff to focus their time on improving patient care and outcomes, and less time on data entry and paper shuffling.

XIFIN LIS also includes the following Input screens and functions:

  • Accessioning
  • EMR Integration
  • Specimen Management
  • Management Reporting
  • Batch Resulting
  • Batch Printing
  • Result Reporting
  • Summary Reports
  • Clinical Trials
  • Report Distribution
  • Control & Reagent Management
  • Remote Ordering & Resulting
  • Billing Management
  • Test Management
  • Workflow Configuration
  • Screen Configuration
  • Instrument Management
  • Quality Control Management
  • Auto-Verification
  • Send-Out Managmenet
  • Reflex Ordering
  • Plate Mapping
  • Macro Management
  • Result Distribution

Blog Post: How to Prepare Your Lab for Next-Gen Sequencing and Big Data Science
With the growing demand for next-generation sequencing (NGS), from bases to whole genomes, and the growing demand for sequence-based drug discovery applications and diagnostic testing, there’s no denying that labs will need to accommodate a huge amount of data very soon.

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Blog Post: What You Need To Know About TCPC Programs
XIFIN hosted a webinar on how to Boost Your Lab's Revenue with an Effective TCPC Program. In case you missed it, here is an overview of the big takeaways

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Blog Post: Boost Your Lab's Revenue with an Effective TCPC Program
TCPC programs are a smart way for labs to drive new revenue and build stronger partnerships.

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Free XIFIN White Paper
Adopting Cloud-Based Technology: Key Considerations For Laboratory CEOs

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Dynamic Reporting That Drives Loyalty and Engagement with Your Clients

Comprehensive consolidated reports maximize your value and impact - combine all individual testing results into a single comprehensive summary report.

Thinking of Building or Upgrading Your Own LIS? Read This First.

The Build vs Buy Conundrum of Laboratory Information Systems

SaaS-based information systems eradicate system silos and allow labs to more easily integrate, communicate and exchange information with other systems, as opposed to the siloed solutions labs build for themselves. Plus, you never have to worry if the system expert suddenly is no longer available. For more detail on the importance of investing in SaaS-based LIS systems, read XIFIN’s “Buy vs. Build” white paper.

Download White Paper

Adopting Cloud-Based Technology: Key Considerations for CEOs

Watch this video to learn more about the trends driving adoption of cloud-based technology. Standardizing on cloud-based technologies is a strategic decision. Learn how one laboratory, Applied Diagnostics, is using cloud technology across its entire organization, enabling it to participate in the value-based model while scaling its operations from a local provider to a regional business.

  • Learn how to standardize your laboratory with cloud-based solutions
  • Improve operational efficiencies & position your organization to seamlessly address the challenges of new technologies
  • Understand the benefits & trade-offs of cloud-based solutions
  • Get insight on how to choose the right cloud vendor
  • Learn how to transform data into knowledge
  • Identify opportunities for your own organization

Boost Your Lab's Revenue Stream with an Effective TCPC Program


To help counteract ongoing lab revenue constriction, TCPC programs are a smart way for labs to drive new revenue and build stronger partnerships with physician clients.

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View this XIFIN-hosted information-packed webinar that explains how to drive new revenue and build stronger relationships with clients and partners with a TCPC program.

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Get the datasheet on how technical component and professional component (TCPC) programs are a smart way for labs to drive new revenue sources as well as to build stronger partnerships with physician clients.


Single Integrated Platform, More Efficient Operations, Faster & More Accurate Claims, Richer Data

XIFIN LIS is part of a complete cloud-based laboratory platform that manages data from patient to payment. This platform includes XIFIN RPM for optimized revenue cycle management (RCM). Together, the integrated clinical data generated by XIFIN LIS and the detailed financial information from XIFIN RPM form the basis for insightful business intelligence that will help your laboratory thrive. Used together, the reimbursement process is expedited, as data is exchanged in real-time along with supporting documentation for clinical evidence and appeals support.

“The XIFIN application is top notch and allows a lot of customization options. It’s one of the best I have used. Furthermore, integrating XIFIN’s LIS and RPM revenue cycle management solutions has meant cleaner claims submitted faster. It’s improved our accounts receivables and has eliminated keystroke and misinterpretation errors. We also now have a better understanding of how a change in one system can impact the other system.”

Robert Embree

EVP of Operations, Pathnostics

“What's better? Me with an IT dept that is stretched thin or a company like XIFIN, that has a dedicated staff to develop a product and a staff to defend themselves. Security and these related issues will be better handled by those vendors. And the better solution is cloud for that reason.”

Fritz Gartner

CEO, Applied Diagnostics

“One of the nice features of XIFIN LIS is that it allows you to take information that the pathologist is trying to convey to the oncologist and put it right up front. And then all the back pages are the details behind each of the different additional testing that’s done.”

Dan Angress

CEO, Angress Consulting

A Complete Suite of Solutions


Our comprehensive revenue performance management solution features workflow functionality designed to help laboratories maximize their claims.

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Open up new revenue opportunities, improve quality assurance and minimize risk through secondary digital consultations and professional networking with XIFIN ProNet. 

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A Precision Medicine Informatics platform that uniquely integrates and visualizes clinical, diagnostic and financial data, enabling healthcare professionals to gain insights, make better decisions, and improve outcomes.

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Blog Post: 5 Best Practices - Secure Value from Digital Transformation Initiatives

The digital transformation wave is going to push your laboratory and profession to their limits if it hasn’t already.