Proteomic Map of Hundreds of Cancer Cell Lines Helps Discover New Biomarkers

Researchers have generated a pan-cancer proteomic atlas of cancer cell lines that shows the cancer proteome can be interrogated to find vulnerabilities, including drug sensitivities.

Using a data-independent acquisition mass spectrometry (DIA-MS) approach, the team generated the proteomes of nearly 950 cancer cell lines, representing more than 40 different cancer types, a resource they have dubbed the ProCan-DepMapSanger. By combining this proteomic dataset with other molecular and phenotypic data, the researchers uncovered thousands of protein biomarkers tied to cancer vulnerabilities, including ones not found at the transcriptome level.

“[T]his dataset represents a major resource for the scientific community, for biomarker discovery, and for the study of fundamental aspects of protein regulation that are not evident from existing molecular datasets,” Reddel and colleagues wrote. “This will enable the identification of targets (including cell surface proteins) and treatments for validation in cancer tissue cohorts, with applications in precision oncology.”

Tags: Precision Oncology

Source: https://www.genomeweb.com/cancer/proteomic-map-hundreds-cancer-cell-lines-helps-discover-new-biomarkers