ACMG Updates Gene List for Labs Reporting Clinical Sequencing Secondary Findings

The American College of Medical Genetics and Genomics has updated its list of genes for which it recommends laboratories report findings. It now includes 73 genes.

The ACMG first recommended in 2013 that labs conducting clinical genome or exome sequencing report secondary findings for a set of 56 genes. This list encompassed genes in which variants predisposed people to conditions like hereditary cancer syndromes and were medically actionable. An update to the list in 2016 added four more genes but removed one.

As it reported today in Genetics in Medicine, an ACMG working group has now added 14 more genes to its list of genes for which secondary results should be reported. In an accompanying policy update, the working group further noted its plans to update this list — now dubbed ACMG SF v3.0 — yearly.

Source: https://www.genomeweb.com/clinical-sequencing/acmg-updates-gene-list-labs-reporting-clinical-sequencing-secondary-findings