Colorectal Cancer Risk Linked to Common, Rare Variants

An international team led by investigators at the Fred Hutchinson Cancer Research Center has identified a combination of rare and common genetic variants coinciding with colorectal cancer (CRC) susceptibility.

The researchers started by doing whole-genome sequencing on more than 2,100 CRC cases and controls, using variants imputed from these and other data in a two-stage genome-wide association study that included nearly 125,500 individuals with or without CRC. The findings, appearing online today in Nature Genetics, revealed 40 previously undocumented CRC-associated variants and 55 variants implicated in CRC risk in prior studies.

Source: https://www.genomeweb.com/sequencing/colorectal-cancer-risk-linked-common-rare-variants#.XAl3gNtKiUk