TPMT Gene Analysis is a New Medi-Cal Benefit

Effective for dates of service on or after November 1, 2018, CPT-4 code 81335 (TPMT [thiopurine S-methyltransferase], gene analysis, common variants) is a Medi-Cal benefit. A Treatment Authorization Request (TAR) is required when billing for the gene analysis. The TAR must document that the patient is undergoing thiopurine therapy and that the patient has severe or prolonged myelosuppression. CPT-4 code 81335 may only be billed once in a lifetime.

This information is reflected in the following provider manual(s):